The US has condemned a speech by Syria's President Assad that denounced his opponents as "puppets of the West".
The state department said a peace plan outlined by Mr Assad was "detached from reality", calling it "another attempt by the regime to cling to power".
The EU reacted by restating that the Syrian president had "to step aside and allow for a political transition".
The UN estimates that more than 60,000 people have been killed in the uprising, which began in March 2011.
Sunday's televised speech was Bashar al-Assad's first public address since June.
He denounced opponents as "enemies of God and puppets of the West" and said Syria wanted to negotiate with the "master not the servants".
He said Syria had not rejected diplomatic moves but insisted it would not negotiate with people with "terrorist" ideas.
Mr Assad set out a plan involving a national dialogue conference and a referendum on a national charter.
In Washington, state department spokeswoman Victoria Nuland said the speech was "yet another attempt by the regime to cling to power and does nothing to advance the Syrian people's goal of a political transition".
She added that the initiative "is detached from reality" and undermines efforts by international peace envoy Lakhdar Brahimi.
She repeated calls for President Assad to leave office - as did EU foreign policy chief Catherine Ashton.
"We maintain our position that Assad has to step aside and allow for a political transition," Baroness Ashton's office said in a statement.
Turkish Foreign Minister Ahmet Davutoglu called his remarks "repetitions of what he's said all along", while UK Foreign Secretary William Hague said "the empty promises of reform fool no-one".
In his speech Mr Assad set out a series of steps he said would provide a solution to the crisis:
Outside powers to stop arming what he called "terrorist groups"
The army would then halt military operations, while reserving the right to defend state interests
The government would then contact what he termed "Syrian individuals and political parties" to engage in a conference of national dialogue
The conference would try to establish a national charter that would be put to a referendum, leading to parliamentary elections and a new government
The BBC's James Reynolds says the president's latest words are unlikely to persuade any in the opposition that he is ready to discuss a viable transition.
The opposition Syrian National Coalition (SNC) rejected the proposals.
Spokesman Walid Bunni told Reuters news agency his group would accept nothing less than the departure of Mr Assad and his government.
In recent months opposition forces have gained control of swathes of territory in northern Syria.
But rebel efforts to gain ground in and around major cities including Damascus have met with stiff resistance and increasingly destructive air strikes.
--Courtesy of BBC News